DC-CHOL is an effective steroid-based transfection agent and lipid formulation reagent. It is primarily employed in the preparation of various carriers, including microbubbles for contrast ultrasound imaging, liposomes, and precursor liposome precursors for liposomal glutathione (L-GSH).
| Product Name | DC-CHOL |
| Chemical Name | 3β- [N- (N, N-dimethylaminoethane) carbamoyl] cholesterol hydrochloride |
| CAS No. | 166023-21-8 |
| NMPA CDE registration no. | / |
| USFDA DMF No. | / |
| Quality grade | Reagent |
| Quality standards | Manufacturer's standard |
| Molecular Formula | C32H57N2O2Cl |
| Applications and examples | Sterol-based transfection agents: DC-Chol/DOPE, a low-toxicity, high-efficiency nucleic acid transfection combination, typically in ratios of 1:1 or 3:1.Cationic lipid microbubble contrast agents: Novel cationic ultrasound contrast agents prepared using DC-Chol can efficiently encapsulate genes and significantly enhance in vivo imaging capabilities. |
| Product code | O02003 |
| Package sizes | 1g |
| Storage condition | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Compared to other cationic lipids such as DOTMA or DOTAP, liposomes prepared from DC-Chol and DOPE (at a ratio of 1:1, molar/molar) exhibit only 50% of nanoparticles carrying charge at pH 7. This renders DC-Chol/DOPE liposomes more prone to dissociation compared to DOTAP/DOPE and DOTAM/DOPE liposomes, demonstrating faster mRNA delivery and enhanced cellular transfection efficiency.
DC-CHOL is a derivative of cholesterol, synthesized through a chemical reaction between dimethylamine and cholesterol. The aminoethylglycine ester formed during its synthesis possesses degradability. It is a commonly used cationic lipid for preparing lipid nanoparticles (LNPs), providing LNPs with positive charge and stabilizing their membrane structure.
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