DSG-PEG2000 can be used for preparing liposomes for siRNA delivery. In mouse tumor experiments, it was found that when DSG-PEG2000 is used as a component in LNPs for siRNA delivery, it effectively prevents siRNA leakage, enhances the stability and integrity of LNPs in the bloodstream, reduces siRNA accumulation in the liver, and simultaneously increases siRNA accumulation in the spleen and tumor area.
| Product Name | l,2-Distearoyl-rac-glycerol--3-methoxypolyethylene glycol（DSG-PEG2000） |
| Chemical Name | l,2-Distearoyl-rac-glycerol--3-methoxypolyethylene glycol |
| CAS No. | 308805-39-2 |
| NMPA CDE registration no. | / |
| USFDA DMF No. | / |
| Quality grade | Reagent |
| Quality standards | Manufacturer's standard |
| Molecular Formula | C40H78NO5(C2H4O)n,n≈45 |
| Applications and examples | DSG-PEG2000 can be used for the development of liposomes for siRNA delivery. In mouse tumor experiments, it was found that when DSG-PEG2000 is used as a component in LNPs for siRNA delivery, it can effectively prevent siRNA leakage, enhance the stability and integrity of LNPs in the bloodstream, reduce siRNA accumulation in the liver, and simultaneously increase siRNA accumulation in the spleen and tumor areas [1]. |
| Product code | F11001 |
| Package sizes | 1kg |
| Storage condition | The product should be transported in a refrigerator, protected from light (for less than 2 weeks). It should be stored at -20 ± 5℃ in an inert atmosphere, protected from light. To avoid water absorption, naturally warm up to room temperature before unpacking. It is valid for 1 year when used and stored properly. |
PEG lipids can reduce the aggregation of LNPs, thereby enhancing their stability. Optimization of PEG can reduce the clearance of LNPs mediated by the kidney and mononuclear phagocyte system, thus prolonging their circulation time in the bloodstream. Additionally, PEG lipids can be utilized to conjugate specific ligands onto LNPs for targeted delivery.
DSG-PEG2000 is an off-white solid powder, freely soluble in methanol, chloroform, and partially soluble in water.
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