As a commonly used helper lipid, DOPE exhibits strong synergistic effects in the preparation of cationic liposomes. Liposomes formulated with DOPE have been developed into commercial transfection reagents and are widely used in basic research. Additionally, DOPE is also an essential helper lipid in cationic lipid formulations and marketed liposomal vaccines such as Epaxal and Inflexal V.
NMPA CDE registration no.: /USFDA
DMF no.: 028884
| Product Name | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE |
| Chemical Name | / |
| CAS No. | 4004-05-1 |
| NMPA CDE registration no. | / |
| USFDA DMF No. | 028884 |
| Quality grade | Injection |
| Quality standards | Manufacturer's standard |
| Molecular Formula | C41H78NO8P |
| Applications and examples | DOPE is a phosphatidylethanolamine with two unsaturated chains (C18). It is commonly used as a helper lipid in the preparation of cationic liposomes, where it exhibits strong synergistic effects. Its primary applications include use in cationic lipid formulations and marketed liposomal vaccines. |
| Product code | S03005 |
| Package sizes | 1g, 10g, 50g |
| Storage condition | This product should be stored and transported in a light-protected and sealed container at a temperature of −20 ± 10°C, with retesting conducted annually. |
DOPE is the most commonly used helper lipid. Liposomes prepared using DOPE demonstrate better fusogenicity and transfection efficiency compared to those prepared using DOPC or CHO. DOPE can facilitate self-assembly and endosomal escape of liposomes. When combined with cationic lipids, DOPE can enhance the transfection efficiency of naked siRNA.
DOPE is a phosphatidylethanolamine with two unsaturated chains (C18). The unsaturated tails facilitate the formation of more fluid lipid bilayers and can also adopt a hexagonal (HII) phase. The HII phase aids in promoting fusion between lipid bilayers and intracellular membranes, facilitating the release of nucleic acids into the cytoplasm.
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