AVT specializes in excipients for high-end injections represented by liposomes and fat emulsions.
In the fat emulsion injections, egg yolk lecithin is used as an emulsifier to achieve good stability and safety.
Oleic acid and sodium oleate are usually used as co-emulsifiers. They are strong defoaming agents as well as solubilizers, thus are widely used in fine chemical products such as cosmetic, soap, and pesticide. With small amount added in the fat emulsion, the HLB value of egg yolk lecithin is adjusted, which is beneficial to forming smaller emulsion droplets and increasing the absolute value of the potential, and thus a stable O/W system is formed.
Product Name | Oleic Acid (for Injection) |
Chemical Name | (Z)-Octadic-9-enoic acid |
CAS No. | 112-80-1 |
NMPA CDE registration no. | F20190001047(A) |
USFDA DMF No. | / |
Quality grade | Injection |
Quality standards | Conforms with USP, JP, ChP,EP standards |
Molecular Formula | C18H34O2 |
Applications and examples | Fat emulsion co-emulsifier |
Product code | O04001 |
Package sizes | 10kg |
Storage condition | Pure form -20°C 3 years 4°C 2 years Powder -20°C 3 years |
1. Oleic acid can be used as an emulsifier in food and topical pharmaceutical preparations. It can also be used as a transdermal accelerator for transdermal preparations. It can improve the bioavailability of poorly water-soluble drugs in tablet form and can be used as a part of matrix for soft capsules.
2. Oleic acid can also be used as an emulsifier in fat emulsion preparations to improve the emulsification effect and increase the formulation stability.
Representative products using oleic acid as an excipient including Ritonavir soft capsules, alprostadil injection, clevidipine butyrate fat emulsion injection, propofol injection, etc.
Oleic acid is generally extracted from plants. In addition to the main component, it often contains some palmitic acid, linoleic acid and other other fatty acids.
Oleic acid is insoluble in water, but has good solubility in organic solvents such as ethanol, ether, and chloroform, and can be mixed in any proportion.
Oleic acid used in cosmetics has low toxicity and slight irritation to the skin, but has certain irritation to the eye. Pure oleic acid will cause obvious corrosion to the body and irritation to the eye.
The toxicity of oleic acid to the human body is mainly manifested in cytotoxicity and protease inhibition. Oleic acid is not carcinogenic in itself, but for patients with prostate cancer, colon cancer and rectal cancer, dietary intake will cause disease progression.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.
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