Dioleoylphosphatidylethanolamine (DOPE) is one of the most widely used auxiliary phospholipids, exhibiting strong synergistic effects in the preparation of cationic liposomes. Applications: liposomes, lipid nanoparticles, and modulation of phospholipid membrane fluidity.
| Product Name | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE |
| Chemical Name | / |
| CAS No. | 4004-5-1 |
| NMPA CDE registration no. | / |
| USFDA DMF No. | 028884 |
| Quality grade | Injection |
| Quality standards | Manufacturer's standard |
| Molecular Formula | C41H78NO8P |
| Applications and examples | DOPE is a phosphatidylethanolamine with two unsaturated chains (C18). It is commonly used as a helper lipid in the preparation of cationic liposomes, where it exhibits strong synergistic effects. Its primary applications include use in cationic lipid formulations and marketed liposomal vaccines. |
| Product code | S03005 |
| Package sizes | 1g, 10g, 50g |
| Storage condition | This product should be stored and transported in a light-protected and sealed container at a temperature of −20 ± 10°C, with retesting conducted annually. |
DOPE is the most commonly used helper lipid. Liposomes prepared using DOPE demonstrate better fusogenicity and transfection efficiency compared to those prepared using DOPC or CHO. DOPE can facilitate self-assembly and endosomal escape of liposomes. When combined with cationic lipids, DOPE can enhance the transfection efficiency of naked siRNA.
DOPE is a phosphatidylethanolamine with two unsaturated chains (C18). The unsaturated tails facilitate the formation of more fluid lipid bilayers and can also adopt a hexagonal (HII) phase. The HII phase aids in promoting fusion between lipid bilayers and intracellular membranes, facilitating the release of nucleic acids into the cytoplasm.
DOPE is a neutral, unstable auxiliary phospholipid, which stabilizes the bilayer membrane and reduces the toxicity of cationic components;
It can disrupt lipid membranes, destabilizing the endosomal membrane within cells to promote the release of DNA and RNA, and assisting cationic liposomes in penetrating cells;
It can also determine the morphology of nucleic acid-liposome complexes, transitioning lipid structures from the lamellar Lα phase to the hexagonal HII phase, thereby enhancing the fusogenicity of the complexes and significantly improving transmembrane efficiency.
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