Product Name | 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine(for injection) DPPC |
Chemical Name | / |
CAS No. | 63-89-8 |
NMPA CDE registration no. | F20180000192 |
USFDA DMF No. | 19820 |
Quality grade | Injection |
Quality standards | Manufacturer's standard |
Molecular Formula | C40H80NO8P |
Applications and examples | Amikacin liposome inhalation suspension, Surfaxin intratraqueal suspension |
Product code | S01004 |
Package sizes | 1kg |
Storage condition | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
We supply DPPC phospholipid with a high purity of over 99%;
Because the fatty acids used to prepare DPPC can be customized, various DPPC molecules with controllable phase transition temperatures can be obtained;
DPPC is also a major component of pulmonary surfactants for respiratory distress syndrome management;
DPPC exhibits unparalleled biocompatibility and safety compared to other synthetic phospholipids;
And it is also the preferred phospholipid and a primary component of liposomal inhalers.
DPPC is an endogenous substance in the human body and is one of the main components of the human pulmonary surfactant, accounting for over 60% of the total. It is distributed on the surface of the liquid layer lining the alveolar space and serves to reduce alveolar surface tension, maintaining the relative stability of alveolar volume while preventing fluid from leaking into the alveoli from pulmonary capillaries. Because DPPC is one of the natural phospholipid components of the alveoli, it possesses biological compatibility and safety that other synthetic phospholipids lack.
As API:
Pulmonary surfactant: DPPC phospholipid is an important component of natural pulmonary surfactant and is widely used to treat neonatal respiratory distress syndrome (NRDS). In this application, DPPC, as an API, helps reduce alveolar surface tension, prevent alveolar collapse, and improve respiratory function.
Research tools: In biomedical research, DPPC 63-89-8 is often used as an API for model membrane systems to study the physicochemical properties of cell membranes and the functions of membrane proteins. These studies help understand the structure and function of cell membranes and provide a theoretical basis for the development of new drugs.
As a drug excipient:
Liposome drug delivery system: DPPC phospholipid is widely used as a drug excipient to prepare liposomes, which can encapsulate drug molecules and improve the stability and bioavailability of drugs. Liposomes can protect drugs from degradation by enzymes in the body, extend the half-life of drugs, and achieve targeted delivery.
Vaccine carrier: DPPC phospholipid is also used as a vaccine delivery carrier, which can enhance the immunogenicity of antigens and improve the efficacy of vaccines. By encapsulating antigens in DPPC liposomes, more effective antigen presentation can be achieved, inducing a stronger immune response.
Gene therapy: In gene therapy, DPPC liposomes can be used to deliver nucleic acids (such as DNA, RNA) to target cells. DPPC liposomes can protect nucleic acids from degradation in the body and promote their entry into cells, thereby improving the efficiency of gene therapy.
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