AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
dppc cholesterol

DPPC

Dipalmitoylphosphatidylcholine (DPPC) is a synthetic phospholipid. As an excipient, it is a major component of biological membranes, and due to its bilayer structure's ability to encapsulate drug molecules, DPPC phospholipid is also a common component of liposomal drug delivery systems. As an active ingredient (API), it is primarily present in exogenous pulmonary surfactants.

DESCRIPTION of DPPC PHOSPHOLIPID

Product Name1,2-Dipalmitoyl-sn-glycero-3-phosphocholine(for injection) DPPC
Chemical Name/
CAS No.

63-89-8

NMPA CDE registration no.F20180000192
USFDA DMF No.19820
Quality gradeInjection
Quality standardsManufacturer's standard
Molecular FormulaC40H80NO8P
Applications and examplesAmikacin liposome inhalation suspension, Surfaxin intratraqueal suspension
Product codeS01004
Package sizes1kg
Storage condition

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Advantages of DPPC PHOSPHOLIPID

We supply DPPC phospholipid with a high purity of over 99%;

Because the fatty acids used to prepare DPPC can be customized, various DPPC molecules with controllable phase transition temperatures can be obtained;

DPPC is also a major component of pulmonary surfactants for respiratory distress syndrome management;

DPPC exhibits unparalleled biocompatibility and safety compared to other synthetic phospholipids;

And it is also the preferred phospholipid and a primary component of liposomal inhalers.


DPPC Product Properties

DPPC is an endogenous substance in the human body and is one of the main components of the human pulmonary surfactant, accounting for over 60% of the total. It is distributed on the surface of the liquid layer lining the alveolar space and serves to reduce alveolar surface tension, maintaining the relative stability of alveolar volume while preventing fluid from leaking into the alveoli from pulmonary capillaries. Because DPPC is one of the natural phospholipid components of the alveoli, it possesses biological compatibility and safety that other synthetic phospholipids lack.


DPPC Phospholipid Applications


As API:

Pulmonary surfactant: DPPC phospholipid is an important component of natural pulmonary surfactant and is widely used to treat neonatal respiratory distress syndrome (NRDS). In this application, DPPC, as an API, helps reduce alveolar surface tension, prevent alveolar collapse, and improve respiratory function.

Research tools: In biomedical research, DPPC 63-89-8 is often used as an API for model membrane systems to study the physicochemical properties of cell membranes and the functions of membrane proteins. These studies help understand the structure and function of cell membranes and provide a theoretical basis for the development of new drugs.


As a drug excipient:

  • Liposome drug delivery system: DPPC phospholipid is widely used as a drug excipient to prepare liposomes, which can encapsulate drug molecules and improve the stability and bioavailability of drugs. Liposomes can protect drugs from degradation by enzymes in the body, extend the half-life of drugs, and achieve targeted delivery.

  • Vaccine carrier: DPPC phospholipid is also used as a vaccine delivery carrier, which can enhance the immunogenicity of antigens and improve the efficacy of vaccines. By encapsulating antigens in DPPC liposomes, more effective antigen presentation can be achieved, inducing a stronger immune response.

  • Gene therapy: In gene therapy, DPPC liposomes can be used to deliver nucleic acids (such as DNA, RNA) to target cells. DPPC liposomes can protect nucleic acids from degradation in the body and promote their entry into cells, thereby improving the efficiency of gene therapy.

Have Any Questions?

If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.

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