CHO-HP is a high-purity parenteral pharmaceutical excipient produced under GMP conditions. Different from the commonly used animal tissue extraction method to produce cholesterols in China, CHO-HP is semi-synthesized using lanolin as raw material. The high purity (> 99%) and freedom from virus contamination due to animal tissues contribute to its long-term use in several internationally marketed liposome products.
NMPA CDE registration no.: F20170000106(A)
USFDA DMF no.: 024780
| Product Name | CHO（lanolin origin）CHO-HP |
| Chemical Name | High purity cholesterol CHO-HP |
| CAS No. | 57-88-5 |
| NMPA CDE registration no. | F20170000106(A) |
| USFDA DMF No. | 024780 |
| Quality grade | Injection |
| Quality standards | Conforms with USP, EP, JP, ChP standards |
| Molecular Formula | C27H46O |
| Applications and examples | CHO-HP (animal-derived) is suitable for use in formulations of emulsions, liposomes, and lipid nanoparticles (LNPs). Additionally, it is a key excipient in serum-free culture media. CHO promotes the growth of most cells and is an essential component for the growth of certain cells, such as myeloma cells. |
| Product code | O01001 |
| Package sizes | 5g, 10g, 50g |
| Storage condition | It is stable at room temperature, but sensitive to light, so it should be protected from light, sealed and stored properly. The shelf life reaches up to 5 years. |
CHO-HP can insert into the phospholipid bilayer of liposomes, interacting with phospholipid molecules to modulate the fluidity of the liposome membrane. Its effect varies with temperature changes;
As CHO-HP is amphiphilic, possessing both hydrophilic and hydrophobic properties, it can enhance the stability of liposomes by regulating the liposome membrane.
Cholesterol, also known as cholestane, is a cyclopentane polyhydrophenanthrene derivative. At temperatures above the phase transition temperature, CHO reduces the mobility of phospholipid fatty acid chains, thereby decreasing the fluidity of phospholipid molecules. Conversely, at temperatures below the phase transition temperature, it prevents the interaction between phospholipid fatty acid chains, thereby preventing a significant decrease in the fluidity.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.
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