Cholesterol In Liposomes, Role Of Cholesterol In Liposomes

TYPES OF CHOLESTEROL IN LIPOSOMES

Cholesterol (lanolin origin)

1. Trade name: CHO-HP; 2. Name: Cholesterol (for injection); 3. Chemical name: Cholest-5-en-3β-ol; 4. Molecular formula: C27H46O; 5. CAS number: 57-88-5; 6. DMF number: 024780; 7. EINECS number: 200-353-2; 8. CDE registration number: F20170000106; 9. Grade: pharmaceutical injectable grade; 10. Quality standards: USP, EP, CP; 11. Cholesterol is added in liposomal formulation mixture for following purpose (Usages): liposome membrane material, emulsifier; 12. Solubility: easily soluble in methanol, ethanol and chloroform, insoluble in water; 13. Molecular weight: 386.7; 14. Storage conditions: Room temperature; 15. Precautions: avoid strong acid, strong alkali and strong oxidizing substances.

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Cholesterol (plant origin)

1. Trade name: CHO-HP; 2. Name: Cholesterol (for injection); 3. Chemical name: Cholest-5-en-3β-ol; 4. Molecular formula: C27H46O; 5. CAS number: 57-88-5; 6. Grade: pharmaceutical injectable grade; 7. Quality standards: manufacturer's standard; 8. Cholesterol is added in liposomal formulation mixture for following purpose (Usages): liposome membrane material, emulsifier; 9. Solubility: easily soluble in methanol, ethanol and chloroform, insoluble in water; 10. Molecular weight: 386.7; 11. Storage conditions: Room temperature; 12. Precautions: avoid strong acid, strong alkali and strong oxidizing substances.

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Role Of Cholesterol In Liposomes

CHO HP is the specific parenteral excipient for liposomes.

It can enhance the stability of liposome membranes and reduce drug leakage.

It can also improve the ability of liposome vesicles to resist changes in external conditions.

How do Cholesterol (For Liposomes) Work?

1. Cholesterol hp is a high-purity parenteral pharmaceutical excipient produced in accordance with GMP guidelines. US DMF number is 024780, NMPA registration number is F20170000106.

2 Different from the animal tissue extraction method commonly used in domestic to produce cholesterol, CHO HP is made from lanolin with semi-synthetic method.

3. The product purity is high (NLT 99%), and there will be no virus contamination of animal tissues. It has been used in multiple marketed liposome products internationally for a long time.

Have Any Questions?

If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.

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