AVT's high-purity cholesterol CHO HP CAS NO.: 57-88-5 is obtained from lanolin after extraction, hydrogenation, and refining. The final purity of Cholesterol HP cas 57 88 5 can reach 99% at least. Cholesterol HP cas 57 88 5 is the specific parenteral excipient for liposomes. Cholesterol HP cas 57 88 5 can enhance the stability of liposome membranes and reduce drug leakage. Cholesterol HP cas 57 88 5 can also improve the ability of liposome vesicles to resist changes in external conditions.
NMPA CDE registration no.: F20170000106(A)
USFDA DMF no.: 24780
| Product Name | CHO（lanolin origin）CHO-HP |
| Chemical Name | High purity cholesterol CHO-HP |
| CAS No. | 57-88-5 |
| NMPA CDE registration no. | F20170000106(A) |
| USFDA DMF No. | 24780 |
| Quality grade | Injection |
| Quality standards | Conforms with USP, EP, JP, ChP standards |
| Molecular Formula | C27H46O |
| Applications and examples | CHO-HP (animal-derived) is suitable for use in formulations of emulsions, liposomes, |
| Product code | O01001 |
| Package sizes | 5g, 10g, 50g |
| Storage condition | It is stable at room temperature, but sensitive to light, so it should be protected from light, sealed and stored properly. The shelf life reaches up to 5 years. |
CHO-HP can insert into the phospholipid bilayer of liposomes, interacting with phospholipid molecules to modulate the fluidity of the liposome membrane. Its effect varies with temperature changes;
As CHO-HP is amphiphilic, possessing both hydrophilic and hydrophobic properties, it can enhance the stability of liposomes by regulating the liposome membrane.
Cholesterol (CAS 57-88-5) plays a key role in drug formulations, especially in drug delivery systems such as liposomes and nanoparticles. It can be inserted into the lipid bilayer membrane, increase the rigidity and stability of the membrane, and prevent the fusion or rupture of liposomes or nanoparticles during storage and transportation, thereby maintaining the integrity and stability of the drug. The presence of cholesterol HP can reduce the fluidity of other lipid components in liposomes or nanoparticles, reduce their oxidation and hydrolysis rates, prevent the degradation of drug components, and prolong their shelf life. As a natural component of the cell membrane, cholesterol HP has good biocompatibility and can reduce the immune response and clearance rate of drug delivery systems in the body, thereby prolonging the half-life and shelf life of drugs in the body. By optimizing the cholesterol content, the release rate of drugs from liposomes or nanoparticles can also be adjusted to achieve a sustained release effect of the drug and further prolong the duration of drug action.
Cholesterol, also known as cholestane, is a cyclopentane polyhydrophenanthrene derivative.
At temperatures above the phase transition temperature, CHO reduces the mobility of phospholipid fatty acid chains, thereby decreasing the fluidity of phospholipid molecules.
Conversely, at temperatures below the phase transition temperature, it prevents the interaction between phospholipid fatty acid chains, thereby preventing a significant decrease in the fluidity.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.
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