Phosphatidylglycerol (PG) phospholipids carry a negative charge due to their negatively charged polar phosphate groups, rendering the entire molecule negatively charged. Depending on the fatty acid chains, common PG phospholipids such as dipalmitoylphosphatidylglycerol (DPPG) and dimyristoylphosphatidylglycerol (DMPG) show significant differences in phase transition temperatures.
| Product Name | 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol,sodium salt,DMPG |
| Chemical Name | 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol |
| CAS No. | 67232-80-8 |
| NMPA CDE registration no. | / |
| USFDA DMF No. | / |
| Quality grade | Injection |
| Quality standards | Manufacturer's standard |
| Molecular Formula | C34H66O10PNa |
| Applications and examples | Liposome |
| Product code | S02002 |
| Package sizes | 1g, 10g, 50g |
| Storage condition | 2-8℃,protected from light. |
Phosphatidylglycerol (PG) phospholipids are widely used in preparation of liposomes;
Lipid particles with negative charges can prevent particle aggregation, thereby enhancing the stability of formulations;
Negatively charged lipid particles are more likely to penetrate cell membranes for delivery.
Lipid particles with negative charges can deliver anti-cancer drugs across cell membranes and even nuclear membranes into cancer cells, thus effectively killing cancer cells. It is of significant importance for cancer treatment. However, the purpose of using PG phospholipids in products such as the Amphotericin B Liposome for Injection (Ambisome) and the Bupivacaine Liposome Injection is to prevent phospholipid membrane fusion and particle aggregation, thereby enhancing formulation stability.
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