Lipid system is an artificial cell membrane, which has an onion-like closed spherical structure. It can protect the drug in its structure and exert a targeted effect.
It is especially suitable as an anticancer drug carrier to improve the therapeutic efficacy of drugs and reduce toxicity, side effects etc.
Liposomes are composed of phospholipids as skeleton membrane and additives. Phospholipids used to prepare liposomes are divided to natural phospholipids and synthetic phospholipids.
AVT is specialized in drug delivery systems such as liposomes, lipid emulsions, and micro-nano targeted formulations. Our products cover natural phospholipids, synthetic phospholipids, functionalized phospholipids, nucleic acid delivery and other sub-fields.
| classification | Product | |||||
| Cholesterol | Cholesterol (lanolin origin) | Cholesterol (plant origin) | ||||
| PC | HSPC | DMPC | DSPC | DOPC | DEPC | DPPC |
| Lyso-PC | P-Lyso-PC | S-Lyso-PC | O-Lyso-PC | |||
| PE | DMPE | DPPE | DSPE | DOPE | DEPE | |
| Lyso-PE | P-Lyso-PE | S-Lyso-PE | O-Lyso-PE | |||
| PG | DMPG | DPPG | DSPG | DOPG | DEPG | |
| PA | DMPA | DPPA | DSPA | |||
| PS | DMPS | DPPS | DSPS | DOPS | ||
| Protective Agents | Trehalose Dihydrate (for Injection) | Trehalose Dihydrate (for Injection)(Sterile) | Sucrose (for injection) | |||
| Other Products | DOTAP | DC-CHOL | Sucrose Octasulfate Potassium | |||
*Injection grade is available for all above products
Among liposome excipients, there are many kinds of phospholipids.
Synthetic phospholipids are preferred excipients with characteristics of stable properties, anti-oxidation, and stabilizing the finished products.
Utilizing mixed phospholipids and cholesterol with different phase transition temperatures can increase stability.
The liposome preparation using sucrose as a freeze-drying protective agent has good stability and reconstitution effect after reconstitution.
Studies have shown that the lyophilized liposome with 10% trehalose as the protective agent has the smallest particle size changes and the best protective efficacy.
Utilizing sucrose octasulfate potassium salt as drug delivery vehicle has improved the in vivo behaviors such as drug therapeutic index, bioavailability, release as well as plasma concentration-time curve.
1. Phospholipid products are used as liposome skeleton membrane materials.
2. Cholesterol cannot form liposomes alone, it needs to form bimolecular membranes together with phospholipids.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.
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