DSPE-MPEG2000 is also known as pegylated phosphatidylethanolamine and exists primarily as a salt. It is hygroscopic and soluble in water. Because of the hydrophobicity of DSPE, DSPE-MPEG2000 can form micelles when dissolved in water. The critical micelle concentration (CMC) is less than 10–5 mol/L, more than 100 times smaller than that of surfactants. Therefore, DSPE-MPEG2000 is an excellent drug-loading micelle material.
NMPA CDE registration no.: F20170000595
USFDA DMF no.: 025329
| Product Name | Phosphatidylethanolamine Pegol; mPEG2000-DSPE; DSPE-mPEG2000 |
| Chemical Name | N-(Carbonyl-methoxypolyethyleneglycol2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt |
| CAS No. | 147867-65-0 |
| NMPA CDE registration no. | / |
| USFDA DMF No. | F20170000595 |
| Quality grade | Injection |
| Quality standards | Manufacturer's standard |
| Molecular Formula | C133H263NO55PNa |
| Applications and examples | Long-circulating liposomes |
| Product code | F01008 |
| Package sizes | 1kg |
| Storage condition | The product should be stored in well-closed containers at -20 ± 5℃, protected from light. It is valid for 24 months when stored normally. |
Solubility in water: 1 g is dissolved in 100 ml of distilled water at 25ºC; it is clear and transparent and dissolves fast;
The molecular weight of polyethylene glycol of MPEG2000-DSPE molecule is approximately 2,000, suitable for the preparation of long-circulating liposomes, so that liposomes will not be captured by MPS-rich tissues immediately after intravenous injection, thus prolonging the circulating time in the blood, and further increasing the chances of entering into the pathological tissues.
Better drug-loading stability maintains the particle integrity of micelles even if diluted by blood.
White powdery solid with certain hygroscopicity, freely soluble in lower alcohols, ketones and chloroform, solubility in water: approximately (3–4) g/100 ml;
MPEG2000-DSPE can disperse in water to form micelles. The critical micelle concentration (CMC) is 102 times lower than that of surfactants, so the drug-loading stability is better, which maintains the particle integrity of micelles even if diluted by blood.
MPEG2000-DSPE micelles are simpler to prepare than liposomes, and have been proven to be targeted and easier to aggregate in solid tumors.
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