AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
Other Products (For Liposome)

Other Products (For Liposome)

TYPES OF LIPOSOMAL PHOSPHOLIPIDS (FOR LIPOSOMES)

Sucrose Octasulfate Potassium Salt

Sucrose Octasulfate Potassium Salt

Sucrose octasulfate potassium salt is widely used as a novel excipient. Pharmaceutical injectable grade, produced in GMP certified plant.
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DOTAP

DOTAP

DOTAP is an effective cationic lipid, originally utilized in commercial products as a gene transfection reagent. It is also applicable as a pharmaceutical excipient in liposomal formulations. Its notable application is EndoTAG-1, a cationic liposomal formulation of paclitaxel. DOTAP imparts a positive charge to EndoTAG-1, allowing it to selectively adhere to tumor endothelial cells (TECs) with negative charges. This selective adsorption facilitates targeted attack on tumor neovasculature without harming healthy vessels, effectively inhibiting tumor growth.
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Sucrose Octasulfate Potassium

Sucrose Octasulfate Potassium

Sucrose octasulfate potassium salt is widely used as a novel excipient. Pharmaceutical injectable grade, produced in GMP certified plant.
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Liposomal Phospholipids (For Liposomes) Effects

01

liposomal Phospholipids are used as skeleton membranes of liposomes.

02

liposomal Phospholipids used to prepare liposomes include natural phospholipids and synthetic phospholipids.

03

Synthetic phospholipids are preferred excipients with characteristics of stable properties, anti-oxidation, and stabilizing the finished products.

How do Phospholipids (For Liposomes) Work?

How do Phospholipids (For Liposomes) Work?

1. Liposomes are composed of phospholipids as the skeleton membrane and additives. The phospholipids used to prepare liposomes include natural phospholipids and synthetic phospholipids.

2. Additives, such as cholesterol, are needed to prepare liposomes. liposome phospholipid undergoes a mixture with  Cholesterol, which is  also an amphiphilic substancear, to prepare stable liposomes. Its function is to adjust the fluidity of the bilayer and reduce the liposomes membrane permeability.

3. In the liposome formulation, special excipients are also utilized. For example, irinotecan liposome Onivyde® uses sucrose octasulfate for gradient drug loading.

4. The lyophilized liposome generally uses sucrose or trehalose as the cryoprotectant for lyophilization.

Have Any Questions?

If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.

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