Polyethylene Glycol (PEG) Lipids

DMG-PEG 2000 is a novel long-circulating lipid material that can be used for preparing liposomes for siRNA transfection, enhancing transfection efficiency. It can also be employed in preparing lipid nanoparticles (LNPs) for the oral delivery of plasmid DNA in vivo, improving the mucosal permeability and delivery efficiency of LNPs.

DSG-PEG2000 can be used for preparing liposomes for siRNA delivery. In mouse tumor experiments, it was found that when DSG-PEG2000 is used as a component in LNPs for siRNA delivery, it effectively prevents siRNA leakage, enhances the stability and integrity of LNPs in the bloodstream, reduces siRNA accumulation in the liver, and simultaneously increases siRNA accumulation in the spleen and tumor area.

ALC-0159 is a PEGylated lipid excipient. It can combine with ALC-0315, cholesterol and DSPC to form lipid nanoparticles for delivery and entrapment of mRNA vaccines. Currently, ALC-0159, as a helper lipid approved for RNA therapies clinically, has been applied in the research on the mRNA (COVID-19) vaccine. Besides, it is also one of the vector components in the BNT162b vaccine against COVID-19.

DSPE-MPEG2000 is also known as pegylated phosphatidylethanolamine and exists primarily as a salt. It is hygroscopic and soluble in water. Because of the hydrophobicity of DSPE, DSPE-MPEG2000 can form ...