S-Lyso-PC can be used in the development of transdermal drug delivery systems, such as liposomes and micelles. It can also inhibit the activity of histone deacetylase 3 (HDAC3), as well as the phosphorylation of signal transducer and activator of transcription 3 (STAT3), thereby inhibiting the proliferation of K562 cells, which could aid in the treatment of chronic myeloid leukemia (CML).
| Product Name | S-Lyso-PC |
| Chemical Name | 1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine |
| CAS No. | 19420-57-6 |
| NMPA CDE registration no. | F20170000006 |
| USFDA DMF No. | / |
| Quality grade | Reagent |
| Quality standards | Manufacturer's standard |
| Molecular Formula | C26H54NO7P |
| Applications and examples | Lysophospholipids can enhance the rate and efficiency of drug release at specific temperatures. Upon reaching the phase transition temperature, lysophospholipids form pores at the edges of the partially melted solid-crystalline phase, increasing the permeability of the liposome membrane and thereby facilitating drug release. |
| Product code | S06003 |
| Package sizes | 1kg |
| Storage condition | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Lyso-PC exhibits significant surfactant properties and potent hemolytic activity, capable of causing the rupture of red blood cells and other cellular membranes, resulting in hemolysis or cell necrosis. However, under normal physiological conditions, the presence and quantity of phospholipases are strictly regulated, ensuring that the organism is not harmed by Lyso-PC.
Compared to phospholipids, lysophospholipids exhibit stronger hydrophilicity, resulting in superior emulsifying properties, which remain stable under conditions of high temperature, low pH, and high ionic concentration. When used in temperature-sensitive liposomes for doxorubicin, lysophospholipids can enhance the rate and efficiency of drug release at specific temperatures. Upon reaching the phase transition temperature, lysophospholipids form pores at the edges of the partially melted solid-crystalline phase, increasing the permeability of the liposome membrane and thereby facilitating drug release.
18:0 Lyso PC, also known as 1-stearoyl-sn-glycero-3-phosphocholine, is a lysophosphocoline connceted to hydrophobic fatty acid tail (stearic acid) by a glycerol.
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