Previous studies have shown that pharmaceutical excipients are inert substances. Therefore, if patients experience adverse reactions during clinical treatment, it is usually attributed to the toxicity of the active ingredients in the medication. As drug research progresses, researchers have gradually discovered that pharmaceutical excipients are not all inert substances, and their safety has begun to be questioned. Improving drug safety and reducing adverse reactions caused by the use of pharmaceutical excipients has become an urgent issue for clinical doctors and drug researchers.
What are pharmaceutical excipients? As the name implies, pharmaceutical excipients refer to the additional additives and shaping agents added during the production of drugs and prescription preparation. Their main purpose is to enhance their utility or reduce side effects in drug formulations. Therefore, pharmaceutical excipients can also be interpreted as a collective term for all the substances that can ensure safety except for the active ingredients. However, with the latest research findings, the inertness of pharmaceutical excipients is also only a relative concept to the main active ingredients in drugs.
In the production process of oral solid preparations, there is increasing research on excipients, and research on the role of pharmaceutical excipients is becoming more and more comprehensive. In any medication, the main part is the drug, which plays a crucial role in the overall efficacy of the medication. However, with respect to the absorption efficacy and time for efficacy development of medication, it is related to pharmaceutical excipients. Pharmaceutical excipients are critical to ensuring that the medication is released at a certain rate and time, and at a certain location in the body. Therefore, appropriate excipients should be chosen in the medication manufacturing process.
First, pharmaceutical excipients, including organic egg yolk lecithin, facilitate the formation of the dosage form, that is, they help form the solid oral dosage form. There are many different forms of solid oral dosage forms, which are formed by different excipients. For example, adding diluents and binders to tablets can give the medication a basic form. Common solid oral dosage forms are mainly tablet and capsule forms.
Second, the choice of pharmaceutical excipients can make the preparation process proceed smoothly. Therefore, when purchasing pharmaceutical excipients wholesale, it is important to consider their impact on the preparation process. Strengthening the application of excipients in the production of solid oral dosage forms can make the formation of the medication faster. For example, the addition of flow aids and lubricants to the production process of solid oral dosage forms can effectively improve the powder properties of the medication and make the production of solid dosage forms smoother.
Third, they can adjust the efficacy of the active ingredient, or improve physiological requirements. Strengthening the application of excipients in the production of solid oral dosage forms can improve the drug's quick-release, sustained-release, enteric-coated, and biologically adhesive properties, thereby effectively improving the quality of the medication.
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